Cysteine and cystine

Cysteine is a sulphur containing amino acid that occurs naturally in foods and can also be manufactured by the body from the amino acid methionine. In the production of cysteine, methionine is converted to S-adenosyl methionine, which is then converted to homocysteine. Homocysteine then reacts with serine to form cysteine.

Cysteine is also found in the body and in food as cystine, an amino acid that contains two cysteines joined together. Cysteine is the precursor for proteins, glutathione, taurine, coenzyme A and inorganic sulphate.

Glutathione, glutamic acid and glycine, is found in all human tissues, with the highest concentrations in the liver and eyes. Glutathione is a potent antioxidant, protecting fatty tissues from the damaging effects of free radicals. The antioxidant activity of glutathione is attributed specifically to the presence of cysteine in the compound.

Cysteine rich foods can help to detoxify the body of chemicals and heavy metals and protect cells from free radical damage. Because it can breakdown proteins found in mucous that settles in the lungs it can be useful in the treatment of many respiratory problems.

Conditions that cysteine can prevent and help to treat

Deficiency of cysteine

Deficiency is relatively uncommon but may be seen in vegetarians with low intake of the plant foods containing methionine and cysteine. Low cysteine levels may reduce one’s ability to prevent free radical damage and may result in impaired function of the immune system and neurodegenerative diseases, including multiple sclerosis, amylotrophic lateral sclerosis (Lou Gehrig’s disease) and Alzheimer’s disease.

Because the production of cysteine involves several nutrients a deficiency of methionine, vitamin B6 (pyridoxine), vitamin B9 (folate), vitamin B12 (cyanocobalamin) and s-adenosyl methionine (SAMe) may decrease the production of cysteine. Certain medications and alcohol consumption can cause deficiencies of these nutrients which will in turn cause a deficiency in cysteine.

It is scientifically recommended that all individuals 1 years of age or greater should consume 25 milligrams of cysteine plus methionine (combined) for every 1 gram of food protein.

Cysteine often gets destroyed in the gastrointestinal tract as a potentially toxic free molecule. Cystine is used to survive the GI Tract or blood serum and get into the cells that can break the bisulphide bond to utilise the freed cysteine molecules.

Highest sources of cystine in milligrams per 100 grams

  • Rabbit (wild) 1243 mg
  • Soya beans 1046 mg
  • Sesame seeds 1012 mg
  • Pheasant 1007 mg
  • Sunflower seeds 952 mg
  • Chlorella (dried) 770 mg
  • Safflower seeds 685 mg
  • Mustard seeds 680 mg
  • Spirulina (dried) 662 mg
  • Oat bran 576 mg
  • Winged beans 545 mg
  • Calf’s liver 490 mg
  • Black walnuts 462 mg
  • Sunflower seeds 451 mg
  • Watermelon seeds 438 mg
  • Peanuts 433 mg
  • Pumpkin and squash seeds 404 mg
  • Chicken 397 mg
  • Quail 394 mg
  • Caviar (fish roe) 389 mg
  • Peanuts 375 mg
  • Whelks 374 mg
  • Brazil nuts 367 mg
  • Sesame seeds 358 mg
  • Flaxseeds 340 mg
  • Lamb’s liver 320 mg
  • Wheat 317 mg
  • Mussels 312 mg
  • Pine nuts 289 mg
  • Beef (lean mince) 278 mg
  • Rabbit (wild) 274 mg
  • Eggs 272 mg
  • Soya beans 268 mg
  • Mackerel  (tinned) 249 mg
  • Salmon (Atlantic farmed) 237 mg
  • Black beans 235 mg
  • Shrimp/prawns 234 mg
  • Walnuts 209 mg
  • Squid 204 mg
  • Quinoa 203 mg
  • Venison 202 mg
  • Almonds 189 mg
  • Turkey 178 mg
  • Cheddar cheese 125 mg
  • Brown rice 96 mg

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