Apigenin is a non-mutagenic bioflavonoid which is presented in leafy plants and vegetables and has significant chemo-preventive activity against UV-radiation. Current research trials indicate that apigenin has powerful anticancer properties.
Apigenin’s anticancer properties
- Reduces DNA oxidative damage.
- Inhibits the growth of human leukaemia cells and induced these cells to differentiate.
- Inhibits cancer cell signal transduction.
- Induces apoptosis.
- Acta as an anti-inflammatory, anti-spasmodic or spasmolytic.
In skin tumours, apigenin may block several points in the process of tumour promotion. This includes inhibiting kinases, reducing transcription factors and regulating cell cycle.
The wide distribution of isoflavonoids and flavonoids, including apigenin, in the plant kingdom, together with their anti-angiogenic and anti-mitotic properties, suggest that these phyto-oestrogens may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumours.
Apigenin has antibacterial properties against the Escherichia coli bacteria and antiviral properties against the Auzesky, herpes simplex and HIV viruses.
Flavonoids, including apigenin, prevent LDL cholesterol oxidation which may help to prevent atherosclerosis and can help to reduce uric acid levels which can help to treat gout and uric acid stones in the bladder or kidneys.
Highest sources of apigenin in alphabetical order
- Artichoke (globe)
- Basil
- Celery
- Chamomile
- Cloves
- Coriander
- Grapefruit
- Hops
- Lavender
- Lemon
- Lemon balm
- Lime
- Liquorice root
- Olives
- Onions
- Oranges
- Oregano
- Parsley
- Peppermint
- Rosemary
- Spinach
- Tangerines
- Thyme
NOTE: Grapefruit can interact with some types of medications.
Related subjects
- A-Z of nutrients
- Cancer
- Gout
- Heart disorders (atherosclerosis, High LDL cholesterol)
- Strokes
- Urinary system disorders (bladder and kidney stones)
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