Apigenin is a non-mutagenic bioflavonoid which is presented in leafy plants and vegetables and has significant chemo-preventive activity against UV-radiation. Current research trials indicate that it may reduce DNA oxidative damage; inhibit the growth of human leukaemia cells and induced these cells to differentiate; inhibit cancer cell signal transduction and induce apoptosis; act as an anti-inflammatory; and as an anti-spasmodic or spasmolytic.
In skin tumours, apigenin may block several points in the process of tumour
promotion, including inhibiting kinases, reducing transcription factors and regulating cell cycle.
The wide distribution of isoflavonoids and flavonoids, including apigenin, in the plant kingdom, together with their anti-angiogenic and anti-mitotic properties, suggest that these phyto-oestrogens may contribute to the preventive effect of a plant-based diet on chronic diseases, including solid tumours.
Apigenin has antibacterial properties against the
bacteria and antiviral properties against the Auzesky, herpes simplex and HIV viruses.
Flavonoids, including apigenin, prevent LDL oxidation which may help to prevent atherosclerosis and can help to reduce uric acid levels which can help to treat
gout and uric acid stones in the bladder or kidneys.